CYTO U Upcoming Webinars
Collapse Engineering Synthetic Immunity to Cancer and Beyond

Engineering Synthetic Immunity to Cancer and Beyond

 

Wednesday, July 11 at 12pm Eastern (U.S. & Canada)

 

Presented by:

Michael Milone
Associate Professor of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, USA

Moderated by Jonni Moore

 

About the Presenter

Dr. Milone received his M.D. and Ph.D. in Experimental Pathology in 1999 from New Jersey Medical School.  After an internship in Internal Medicine and post-graduate medical training in Clinical Pathology and Transfusion Medicine at the Hospital of the University of Pennsylvania, he pursued a post-doctoral research fellowship with Dr. Carl June at the University of Pennsylvania where he studied T cell immunotherapy for cancer and designed the CD19-specific CAR-T cell therapy that became CTL019 (tisagenlecleucel, KymriahTM), the first FDA-approved gene therapy in the US.

Dr. Milone is a founding member of the Center for Cellular Immunotherapies at the University of Pennsylvania. He currently directs a research laboratory focused on basic and translational immunology that includes the design and application of synthetic immunoreceptors for adoptive cellular therapy of cancer and antibody-mediated disease.    

Webinar Summary

This webinar will provide an overview of engineered T cell adoptive immunotherapies that utilize synthetic immunoreceptors termed chimeric antigen receptors (CARs). Topics to be covered include the design of CAR-T cells, approaches to preclinical assessment of efficacy and toxicity and the clinical application of this technology to the treatment of malignant and autoimmune disease.

Learning Objectives

  • Understand the design and mechanism of action of engineered T cell adoptive immunotherapies using chimeric antigen receptors (CARs).
  • Describe some of the challenges to applying CAR-T cell therapy to cancer therapy.
  • Discuss the clinical application of engineered T cells.

Who Should Attend

Scientists, physicians or technologists with an interest in immunotherapy

 

 

Formats Available: Streaming, Live Webcast + Streaming
Original Seminar Date: July 11, 2018
On-Demand Release Date: Available Now

Approved Credit:
  • ASCP: 1 hour CMLE

  • Topics & Pricing InformationTopics & Pricing Information Engineering Synthetic Immunity to Cancer and Beyond
    Collapse Stem Cell Image Cytometry: Quantitative Strategies for Cell Sourcing in Musculoskeletal Tissue Engineering

    Stem Cell Image Cytometry: Quantitative Strategies for Cell Sourcing in Musculoskeletal Tissue Engineering

    Wednesday, August 1 at 12pm Eastern (U.S. & Canada)

    Presented by:

    George Muschler, MD
    Director, Regenerative Medicine Laboratory
    Cleveland Clinic
    Cleveland, Ohio, USA

    About the Presenter

    Dr. Muschler is a nationally-recognized Cleveland Clinic Orthopaedic Surgeon who has devoted his career to advancing patient care through basic and clinical research, and quality management.  As a clinician-scientist, his research laboratory focuses now on adult stem cell biology and tissue engineering, with particular interest in improving methods for harvest and processing of human stem cells and progenitors to enhance tissue regeneration and repair, design and use of quantitative assays of stem cells and progenitor cells relevant to tissue health and aging, and understanding and modulating stem and progenitor cell growth and remodeling kinetics in settings of disease or injury.  Dr. Muschler has authorized over ten patents, including Colonyze, a quantitative automated image analysis system for assay of stem cells and progenitors.

    Webinar Summary

    Cells are the core resource for biological products and biomanufacturing.  No new tissue is formed without cells. However, cell populations from different donors and tissues are highly variable with respect to the concentration, prevalence and the biological potential.  Managing this variation is a profound challenge in the design, fabrication and quality control of cell therapies.  This webinar will discuss the basic research and the development of a robotic, image-based cell picking technology to determine quantitative factors that may predict cell/colony quality.

     

    Formats Available: Streaming, Live Webcast + Streaming
    Original Seminar Date: August 01, 2018

    Approved Credit:
  • ASCP: 1 hour CMLE

  • Topics & Pricing InformationTopics & Pricing Information Stem Cell Image Cytometry: Quantitative Strategies for Cell Sourcing in Musculoskeletal Tissue Engineering
    Collapse Cytometry Part A Spotlight: 16-Color Panel to Measure Inhibitory Receptor Signatures from Multiple Human Immune Cell Subsets

    16-Color Panel to Measure Inhibitory Receptor Signatures from Multiple Human Immune Cell Subsets

    Part of the Cytometry Part A Spotlight Series

     

    Thursday, August 9 at 12pm Eastern (U.S. & Canada)

     

    Presented by:

    Anna Belkina, MD, Ph.D.
    Associate Director
    Flow Cytometry Core Facility
    Boston University School of Medicine
    Boston, MA, USA

     

    Moderated by Pratip Chattopadhyay

     

    More information on this webinar will be posted soon!

     

     

    Formats Available: Streaming, Live Webcast + Streaming
    Original Seminar Date: August 09, 2018
    On-Demand Release Date: Available Now

    Approved Credit:
  • ASCP: 1 hour CMLE

  • Topics & Pricing InformationTopics & Pricing Information Cytometry Part A Spotlight: 16-Color Panel to Measure Inhibitory Receptor Signatures from Multiple Human Immune Cell Subsets
    Collapse Validation, Part 2: Method Validation

    Method Validation

    Part of the Validation Webinar Series

    Monday, August 13 at 12pm Eastern (U.S. & Canada)

    Presented by:

    Virginia Litwin
    Vice President, Immunology
    Caprion Biosciences
    Montreal, QC, Canada

     

    About the Presenter

    Virginia Litwin is a thought-leader in analytical method validation for flow cytometry. Bringing “Cytometry from Bench-to-Bedside” has been the focus of her professional activities since 1999 when she started working in translational medicine at Bristol-Myers Squibb. She co-founded the Flow Cytometry Action Program Committee (APC) within the American Association of Pharmaceutical Scientists (AAPS). The Flow Cytometry APC published the first papers on flow cytometry method and instrument validation which Virginia was invited to present at the FDA Workshop on Clinical Flow Cytometry in 2013.  Virginia is the chair of the Document Development Committee for a new Clinical Laboratory Standards Institute (CLSI) Guideline, H62- Validation of Assays Performed by Flow Cytometry. She is a councilor for both the ISAC and the International Clinical Cytometry Society (ICCS). In addition, she serves on the ICCS Advocacy Committee whose mission is to interface with regulatory agencies.

    In 2011, Virginia edited the book, Flow Cytometry in Drug Discovery and Development (Wiley-Blackwell) with and a Special Issue of the Journal of Immunology Methods on Flow Cytometry Biomarkers and Translational Medicine. More recently, she was the Guest Editors of a Special Issue of Cytometry Part B dedicated to Receptor Occupancy.

    Webinar Summary

    This webinar will include an introduction to the concepts of analytical method validation.  For flow cytometric assays validation carries unique requirements owing to the challenges associated with measuring cells, the lack of cellular reference materials, and the complexity of the instrumentation.  The focus of this webinar will be on how to apply the basic validation principles to flow cytometry and why guidelines appropriate to other methodologies cannot fully be applied to flow cytometry.  One of the most challenging and contentious, but also most important, aspects of cell-based assay validation surrounds the demonstration of method accuracy and linearity.  These points will be addressed in depth.

    Learning Objectives

    In this webinar, you will learn the basic principles of analytic method validation.  We will define each of the validation parameters, and how those parameters can be addressed in flow cytometry method validation. We will also discuss how to interpret the validation data once it is generated and how the validation data influences the final use of the data.

    1. Gain an understanding of the purpose of method validation
    2. Learn the basic validation parameters
    3. Gain an understanding of specific validation considerations for flow cytometry
    4. Gain an understanding of how the type of data generated in the assay influences the design of the method validation
    5. An introduction to interpreting validation data

    Who Should Attend

    The target audience for the Validation series is everyone who is using flow cytometry and wants to generate high quality data (i.e. basic researchers, academia, pharma, biotech, clinical laboratories, environmental labs on boats, you name it).  You get the idea - everybody!

     

    Formats Available: Streaming, Live Webcast + Streaming
    Original Seminar Date: August 13, 2018
    On-Demand Release Date: Available Now

    Approved Credit:
  • ASCP: 1 hour CMLE

  • Topics & Pricing InformationTopics & Pricing Information Validation, Part 2: Method Validation
    Collapse Validation, Part 3: Bringing It All Together

    Bringing It All Together

    Part of the Validation Webinar Series

    Monday, September 10 at 12pm Eastern (U.S. & Canada)

    Presented by:

    Teri Oldaker
    Independent Consultant
    Mission Viejo, CA

     

    About the Presenter

    Teri is a licensed Clinical Laboratory Scientist and certified cytometrist with over 40 years clinical laboratory and 34 years flow Cytometry experience in reference laboratory settings.  She is currently in a  consultant role for a number of clinical laboratories.  Her prior roles include Director of Flow Cytometry at Genoptix, Neogenomics,  Genzyme Genetics and Nichols Institute. Teri has served on the board of the International Clinical Cytometry Society (ICCS) as Secretary /Treasurer and Councillor, and is on the faculty of both the ICCS and Clinical Cytometry Education Network (CCEN) Flow Courses. She is a member of the following ICCS committees:  Advocacy, Certification, and Quality and Standards Committees.  She has authored 4 book chapters, and over 40 publications in the field of flow Cytometry

    Webinar Description

    This webinar will drill-down to the specifics on how to conduct a validation. The course will begin with an introduction to the various regulated environments (CLIA, GLP, GMP, CGLP) and accreditation bodies (CAP, ISO).  Then we will discuss how to conduct the appropriate validation for each environment.  The fit-for-purpose and context-of-use concepts will be introduced. The distinction between assay qualification and validation will be reviewed.  Various strategies to designing method validation protocols will be discussed. These recommendations will be aligned with the upcoming Clinical Laboratories Standards Institute (CLSI) guidelines regarding the number of samples, number of analytical runs, data analysis and acceptance criteria.  Examples of a biomarker validation and a clinical laboratory validation will be presented. Lastly, an update on the progress of a regulatory guidance document for the validation of flow cytometric methods will be presented.

    Learning Objectives

    In the final webinar of the series, you will learn the how to convert the principles learned in the first two webinars into practice in your own laboratory. We will describe what you actually need to do to validate a method.

    1. An introduction to the different types of regulatory environments
    2. Gain an understanding of the difference between assay development, optimization and validation
    3. Gain an understanding of the fit-for-purpose and context-of-use validation approaches
    4. Learn to prepare user friendly documentation

    Who Should Attend

    The target audience for the Validation series is everyone who is using flow cytometry and wants to generate high quality data (i.e. basic researchers, academia, pharma, biotech, clinical laboratories, environmental labs on boats, you name it).  You get the idea - everybody!

     

    Formats Available: Streaming, Live Webcast + Streaming
    Original Seminar Date: September 10, 2018
    On-Demand Release Date: Available Now

    Approved Credit:
  • ASCP: 1 hour CMLE

  • Topics & Pricing InformationTopics & Pricing Information Validation, Part 3: Bringing It All Together
    Collapse Validation, Part 1: Instrument Qualification

    Instrument Qualification

    Part of the Validation Webinar Series

    NEW DATE & TIME

    Monday, October 8 at 12pm Eastern (U.S. & Canada)

    Presented by:

    Cherie Green
    Senior Scientific Manager, Flow Cytometry Biomarkers
    Genentech
    San Francisco, CA

    About the Presenter

    Cherie has been a long standing member of the cytometry community for over 20 years working in hematopathology and biotech laboratories.  She is passionate about development of robust biomarker assays to support all phases of drug development.  Currently, she oversees the Flow Cytometry Biomarker group in the Development Sciences department at Genentech, a member of Roche Group in San Francisco, CA. Her group is responsible for the development and validation of clinical biomarker assays in the areas of infectious, autoimmune, and oncology diseases.  She has served as the co-chair of Flow Cytometry Action Committee of the American Association of Pharmaceutical Scientists (AAPS) and has co-authored many consensus/recommendation papers on topics specific to drug development such as instrument and assay validation, sample stability, and receptor occupancy.  

    Webinar Summary

    The foundation of good data starts with the instrument. While substantial effort is often invested in development and validation of analytical methods or analysis, instrument validation is often neglected.  It is essential to apply the same analytical and scientific rigor to the platform generating the data.  From initial optimization and characterization of performance to establishing QC systems to ensure longitudinal data comparability, instrument validation strategies are critical components of generating robust and reliable data.  This is true for all laboratory environments but particularly relevant for regulated labs providing decision-enabling biomarkers. Generating quality data plays a critical role in bringing new therapeutic options to the medical community; drugs which eventually manifest as successful new treatments for those individuals afflicted with disease.

    Learning Objectives

    In this webinar, you will learn the basic principles of instrument validation. Validation of flow cytometers used in regulated environments provides assurance that the output generated on these instruments is reproducible and precise.  The most relevant elements of instrument validation include testing to verify that an instrument: i) is installed properly and ii) performs as intended.  This includes establishing controlled procedures for installation, maintenance, calibration, cross-instrument standardization, and longitudinal performance monitoring.  This course will review basic concepts of instrument validation and provide examples of each step in the process that can be applied in your lab.

    Who Should Attend

    Anyone interested in getting robust and reliable flow cytometry data.

     

     

     

    Formats Available: Streaming, Live Webcast + Streaming
    Original Seminar Date: October 08, 2018
    On-Demand Release Date: Available Now

    Approved Credit:
  • ASCP: 1 hour CMLE

  • Topics & Pricing InformationTopics & Pricing Information Validation, Part 1: Instrument Qualification
    CYTO U Archived Webinars